ROS Promote Hypoxia-Induced Keratinocyte Epithelial-Mesenchymal Transition by Inducing SOX2 Expression and Subsequent Activation of Wnt/β-Catenin

Figure 7

Schematic of keratinocyte activation by hypoxia treatment: the primary event in this process is the production of ROS in response to hypoxia treatment. ROS function as secondary messengers and stimulate SOX2 expression and subsequent activation of Wnt/β-catenin in HaCaT cells. The activation of Wnt/β-catenin, in turn, induces EMT, accelerates migration, and promotes wound healing.