Novel Application of Eupatilin for Effectively Attenuating Cisplatin-Induced Auditory Hair Cell Death via Mitochondrial Apoptosis Pathway

Figure 1

Eupatilin protected viability of HEI-OC1 cells upon cisplatin toxicity. (a) Effect of cisplatin on HEI-OC1 cells. HEI-OC1 cells were treated with or without various concentrations of cisplatin for 24 h. (b) Effect of eupatilin on cisplatin-induced viability in HEI-OC1 cells. Cells were pretreated with or without various concentrations of eupatilin (5-100 μM) for 4 h followed by 30 μM cotreatment for 24 h except those in the control (ctl) group. Cell viability was measured by CCK8 kit. Values were represented as the from three independent experiments. vs. the nontreated control group; ^## and ^#### vs. the group treated with 30 μM cisplatin alone.

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