Novel Application of Eupatilin for Effectively Attenuating Cisplatin-Induced Auditory Hair Cell Death via Mitochondrial Apoptosis Pathway

Figure 6

Eupatilin protected against cisplatin ototoxicity in transgenic zebrafish. (a) Zebrafish larvae at 4 dpf were exposed to cisplatin in the absence or presence of eupatilin for 24 h. The GFP fluorescence of hair cells was visualized under a fluorescence microscope. (b) Diagram of the assay for (a). (c) Quantification of the number of hair cells per neuromast after the different treatments represented as . vs. the nontreated control group; ^#### vs. the group treated with 30 μM cisplatin alone. Scale bar equals 20 μm.

(a)

(b)

(c)