Empagliflozin Enhances Autophagy, Mitochondrial Biogenesis, and Antioxidant Defense and Ameliorates Renal Ischemia/Reperfusion in Nondiabetic Rats

Table 1

EGTI histology scoring system for renal ischemia/reperfusion injury defined by Chavez et al. [15].

Tissue type	Damage	Score
Tubular	No damage	0
	Loss of brush border (BB) in less than 25% of tubular cells. Integrity of the basal membrane	1
	Loss of BB in more than 25% of tubular cells, thickened basal membrane	2
	(Plus) inflammation, cast formation, necrosis up to 60% of tubular cells	3
	(Plus) necrosis in more than 60% of tubular cells	4
Endothelial	No damage	0
	Endothelial swelling	1
	Endothelial disruption	2
	Endothelial loss	3
Glomerular	No damage	0
	Thickening of the Bowman capsule	1
	Retraction of glomerular tuft	2
	Glomerular fibrosis	3
Tubulointerstitial	No damage	0
	Inflammation, hemorrhage in less than 25% of tissue	1
	Inflammation, hemorrhage in less than 25% of tissue plus necrosis in less than 25% of tissue	2
	Necrosis up to 60%	3
	Necrosis more than 60%	4