Research Article
PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway
Figure 4
PPARγ inhibits the TXNIP/NLRP3 signaling pathway. (a, b) IF staining for TXNIP and the rate of positive cells in the liver (scale bars: 50 μm). (c) Representative western blot and (d) quantitative analysis of TXNIP, NLRP3, ASC, cleaved caspase-1, and mature IL-1β levels normalized against β-actin 24 h after CLP. (; data are shown as the . versus the control group; # versus the control group; € versus the CLP group; $ versus the CLP group; & versus the CLP+GW96 group; γ versus the CLP+GW96 group).
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