Research Article
PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway
Figure 5
PPARγ reduces sepsis-induced liver injury by alleviating inflammatory responses and pyroptosis. (a, b) NLRP3 immunohistochemical staining (scale bars: 50 μm) and the rate of positive cells in the liver. (c–e) Levels of TNF-α, IL-6, and IL-1β in liver tissue. (f–h) The levels of TNF-α, IL-6, and IL-1β in HepG2 and Hep3B cell supernatants (). (i) LDH levels. (j) Cell viability. (; data are shown as the . versus the control group; # versus the control group; € versus the CLP group; $ versus the CLP group; & versus the CLP+GW96 group; γ versus the CLP+GW96 group).
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