Neuroprotective Mechanism of Icariin on Hypoxic Ischemic Brain Damage in Neonatal Mice

<div>Effects of PHTPP treatment on apoptosis in HIBD neonatal mice pretreated with ICA. The numbers of TUNEL-positive cells (green fluorescence in the lower panel), NeuN-positive cells (red fluorescence), and FJC-positive neurons (green fluorescence in the upper panel) in the cerebral ischemic penumbra (small black box in the upper left brain section) in PHTPP-treated HIBD newborn mice detected by tissue immunofluorescence, <svg height="8.55521pt" id="M90" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 27.8368 8.55521" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 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Oxidative Medicine and Cellular Longevity

fig16

Figure 16

Figure 16: Neuroprotective Mechanism of Icariin on Hypoxic Ischemic Brain Damage in Neonatal Mice 