Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury

Figure 9

The potential molecular mechanism of maltol on SCI. Maltol can activate the expression of Nrf2 and facilitate Nrf2’s translocation from the cytosol to the nuclear. Then it promotes mitophagy via enhancing the Nrf2/PINK1/Parkin pathway, ultimately suppressing the neuronal apoptosis in SCI.