Lysionotin Induces Ferroptosis to Suppress Development of Colorectal Cancer via Promoting Nrf2 Degradation

Figure 7

Lys suppresses CRC development in vivo through priming ferroptosis. Seven days following the xenograft, the patient received an intraperitoneal (i.p.) injection of Lys containing 20 mg/kg once every three days for a total of four doses. In order to suppress ferroptosis, Lip1 (10 milligrams per kilogram) was injected intraperitoneally (i.p.) once day after the administration of Lys up to the time of sacrifice. At the end of the 24th day following the xenograft, all of the mice were put to sleep, and the weight and volume of the tumor were measured. (c) The total number of treatments continued till the body weight of the mice was recorded. (d) Histological data of H&E staining performed on samples taken from various experimental groups’ hearts, kidneys, and livers; values: , .

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