Anthocyanin Encapsulated Nanoparticles as a Pulmonary Delivery System

Table 2

The identified anthocyanins and their metabolites in lung tissues of A/JCr mice following inhalation treatment.

Compound	m/z	Rt (min)	Mass error (ppm)	Inhalation treatment
				Control (E-CMC)	HB-CMC	Free HB
Cyanidin-3-O-glucoside	449.1078	9.2	0	—
Cyanidin	287.0550	16.44	0.6	—		—
Cyanidin-3-O-glucuronide	463.0871	16.16	0.5	—	—
Peonidin-3-O-glucoside	463.1235	15.5	0.6	—	—
	[M-H]^-
Protocatechuic acid	153.019	5.9
Hippuric acid	178.051	8.6		—

m/z: mass/charge; Rt: retention time in minutes; control: mice given anthocyanin-free carboxymethyl chitosan (E-CMC) nanocarriers; HB-CMC: haskap berry anthocyanin encapsulated carboxymethyl chitosan nanoparticles; HB: haskap berry extract; indicates metabolites detected using high-resolution mass spectrometry (UPLC/ESI/MS-Q-TOF); and – metabolites not detected.