Review Article

The Role of Bioactive Compounds in Natural Products Extracted from Plants in Cancer Treatment and Their Mechanisms Related to Anticancer Effects

Table 1

AICR’s foods that fight cancer.

Natural productsCompoundsStrong evidenceLimited evidence

ApplesDietary fiber, triterpenoid compounds, flavan-3-ols, flavonolsColorectal cancerLung cancer

AsparagusFlavonols, saponins, inulin, folateEstrogen receptor-negative (ER-) breast cancer

BlueberriesDietary fiber, flavones, vitamin C, flavan-3-ols, anthocyanins, tannins (proanthocyanidins and ellagitannins), flavonols, stilbenes, phenolic acids (mainly chlorogenic acids)Colorectal cancerLung cancer

Broccoli and cruciferous vegetablesGlucosinolates, carotenoids (especially beta-carotene, lutein, and zeaxanthin)Colorectal cancerLung cancer, ER- breast cancer, colon cancer

Brussels sproutsCarotenoids, flavonols, dietary fiber, lignans, vitamin C, glucosinolates, folateColorectal cancerLung cancer, ER- breast cancer, colon cancer

CarrotsCarotenoids, phenolic acids (including chlorogenic acids), polyacetylenes (such as falcarinol)Lung cancer, ER- breast cancer

CauliflowerVitamin C, folate, glucosinolatesLung cancer, colon cancer

CherriesAnthocyanins, beta-carotene, dietary fiber, melatonin, phenolic acids;flavan-3-ols, vitamin C, perillyl alcoholColorectal cancerLung cancer, colon cancer

CoffeeMelanoidins, lignans, phenolic acids (mainly chlorogenic acids), caffeine, diterpenes (cafestol and kahweol) in unfiltered coffeeEndometrial and liver cancersMouth, pharynx, larynx, and skin cancers

CranberriesAnthocyanins, tannins, flavonols, terpenes, phenolic acidsLung cancer

FlaxseedDietary fiber, gamma-tocopherol (a form of vitamin E), lignans, alpha-linolenic acid, phenolic acidsColorectal cancer

GarlicAllium compoundsColorectal cancer

GrapefruitVitamin C, flavanones, coumarins, carotenoids in pink and red grapefruit, terpenes in grapefruit peelLung cancer, esophageal cancer, stomach cancer, ER- breast cancer

GrapesFlavonols, phenolic acids, resveratrol, flavan-3-ols, anthocyanins (in red and purple grapes)Lung cancer

KaleDietary fiber, flavonols, folate, glucosinolates, carotenoids (especially beta-carotene, lutein, and zeaxanthin)Colorectal cancerER- breast cancer, lung cancer, colon cancer

OrangesDietary fiber, flavanones, terpenes in orange peel, vitamin CColorectal cancerLung cancer, stomach cancer, colon cancer

Pulses: dry beans, peas, and lentils (legumes)Dietary fiber, resistant starch, phenolic acids, flacan-3-ols, folate, anthocyanins (in red and black beans), tannins (especially proanthocyanidins), lignans, phytic acid saponinsColorectal cancer

RaspberriesDietary fiber, ellagitannins, vitamin C, phenolic acids, anthocyaninsColorectal cancerLung cancer

SoyIsoflavones (genistein, daidzein, and glycitein), dietary fiber (whole soy foods), phytic acid, phenolic acids, protease inhibitors, folate, sphingolipids, lignans, saponinsColorectal cancerLung cancer, breast cancer

SpinachCarotenoids (especially beta-carotene, lutein, and zeaxanthin), flavonols, vitamin C, dietary fiber, folate, lignansColorectal cancerER- breast cancer, lung cancer, colon cancer

Squash (winter)Vitamin C, carotenoids (beta-carotene, alpha-carotene, beta-cryptoxanthin, lutein, and zeaxanthin)ER- breast cancer, lung cancer, colon cancer

StrawberriesVitamin C, dietary fiber, anthocyanins, phenolic acids (including ellagic acid), stilbenes (mainly resveratrol), flavan-3-ols, tannins (proanthocyanidins and ellagitannins)Colorectal cancerLung cancer, esophageal cancer, colon cancer

TeaFlavan-3-ols, manganese, flavonols, caffeine, L-theanineBladder cancer

TomatoesVitamin C, vitamin A, phytoene, phytofluene, lycopene, beta-caroteneER- breast cancer, lung cancer, colon cancer, bladder cancer

WalnutsPolyphenols, alpha-linolenic acid, phytosterols, melatonin, tannins (proanthocyanidins and ellagitannins)

Whole grainsDietary fiber, phytic acids, resistant starch, lignans, phenolic acidsColorectal cancer