Triptolide Induces Liver Injury by Regulating Macrophage Recruitment and Polarization via the Nrf2 Signaling Pathway

Figure 6

Nrf2 deficiency aggravates the liver injury induced by LPS stimulation after TP pretreatment. (a) Changes in the levels of ALT and AST in WT and Nrf2^−/− mice treated with TP and LPS (). (b) Representative images of HE-stained liver from WT and Nrf2^−/− mice treated with TP and LPS, 200x magnification. (c) RT-PCR analysis of hepatic M1 genes in WT and Nrf2^−/− mice administrated with TP and LPS (). Data are presented as , and vs. WT-control.

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