Sanguinarine-Chelerythrine Fraction of Coptis chinensis Exerts Anti-inflammatory Activity in Carrageenan Paw Oedema Test in Rats and Reveals Reduced Gastrotoxicity

Figure 6

Microscopic examination of the gastric mucosa after hematoxylin-eosin (H&E) staining (×100). Experimental groups (): (a) group receiving investigational alkaloid fraction of C. chinensis containing sanguinarine and chelerythrine 1 mg/kg (SC₁); (b) group receiving investigational alkaloid fraction of C. chinensis containing sanguinarine and chelerythrine 5 mg/kg (SC₅); (c) group receiving investigational alkaloid fraction of C. chinensis containing sanguinarine and chelerythrine 10 mg/kg (SC₁₀); (d) group receiving indomethacin 10 mg/kg (IND); (e) positive control group (CAR); (f) negative control group (CON). In CAR group (e) and SC₁ group (a) generally normal mucosa showing a mild inflammation was detected. In indomethacin receiving animals (d) moderate inflammation and ulceration in the mucosa was present. In (b), (c), and (f), normal mucosa with no inflammation was observed.

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