Sanguinarine-Chelerythrine Fraction of Coptis chinensis Exerts Anti-inflammatory Activity in Carrageenan Paw Oedema Test in Rats and Reveals Reduced Gastrotoxicity

Table 1

The influence of the investigational alkaloid fraction of C. chinensis containing sanguinarine and chelerythrine on the levels of TNFα, PGE₂, and MMP-9 in the homogenized subplantar tissue.

Group	TNFα (pg/mL)	PGE2 (pg/mL)	MMP-9 (pg/mL)
CON		8.797 ± 2.798^###	0.020 ±0.049^####
CAR
SC1
SC5
SC10

TNFα: tumour necrosis factor alpha; PGE₂: prostaglandin E₂; MMP-9: matrix metalloproteinase 9; CON: negative control group; CAR: positive control group; IND: group receiving indomethacin 10 mg/kg; SC₁, SC₅, and SC₁₀ : groups receiving an investigational fraction of C. chinensis containing sanguinarine and chelerythrine (1, 5, and 10 mg/kg, respectively). Data are presented as the . vs. CAR.