[Retracted] Sirtuin 1 Induces Choroidal Neovascularization and Triggers Age-Related Macular Degeneration by Promoting LCN2 through SOX9 Deacetylation

Figure 1

LCN2 inhibits the viability of hypoxic cells and promotes cell apoptosis and angiogenesis. (a) The protein expression of LCN2 in ARPE-19 cells exposed to hypoxia determined by Western blot analysis. (b) The protein expression of LCN2 in hypoxic cells after different transfections determined by Western blot analysis. (c) The content of VEGF, TNF-α and IL-6 in the cell culture fluid determined by ELISA. (d) The viability of hypoxic cells after different transfections determined by CCK-8. (e) The apoptosis of hypoxic cells after different transfections determined by flow cytometry. (f) The migration of hypoxic cells after different transfections determined by Transwell. (g) The angiogenesis of hypoxic cells after different transfection determined by tube formation experiment. , compared with control or cells transfected with sh-NC; ^#, compared with cells transfected with oe-NC. . ^##, ^###, and ^####.

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