[Retracted] Sirtuin 1 Induces Choroidal Neovascularization and Triggers Age-Related Macular Degeneration by Promoting LCN2 through SOX9 Deacetylation

Figure 4

SIRT1 increases the expression of LCN2 by deacetylating SOX9 to promote the formation of laser-induced CNV in mice. (a) The protein expression of SIRT1, acetylated SOX9, and LCN2 in choroid/RPE tissues of mice determined by Western blot analysis. (b) The protein expression of SIRT1, acetylated SOX9, and LCN2 in choroid/RPE tissues of mice after different treatment determined by Western blot analysis. (c), Immunofluorescence staining analysis of mouse choroid/RPE tissues. Green indicates isolectin B4 and CNV area is within the red line. (d) CNV damage area statistics; scale bar: 50 μm. , compared with control or mice treated by sh-NC+oe-NC; ^#, compared with mice treated by sh-SIRT1+oe-NC. . ^####. Measurement data were expressed as the .

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