Capsaicin Prevents Contrast-Associated Acute Kidney Injury through Activation of Nrf2 in Mice

<div>Knockdown of Nrf2 abolishes antiapoptotic effects of capsaicin in CA-AKI. TUNEL-positive tubular cells (a) and cleaved caspase-3 expression level (b) of scRNA- or siRNA-injected mice in the CA-AKI or CA-AKI-plus-capsaicin group. 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id="M60" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 32.2343 8.8423" width="32.2343pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M822 650H589L583 622C660 617 677 607 674 561C672 534 664 481 647 390L600 137H596L273 650H126L120 622C176 620 194 615 207 594C221 571 225 557 214 504L161 257C141 166 129 112 121 85C108 42 83 30 29 28L23 0H260L266 28C193 33 173 42 176 89C178 122 186 172 202 255L256 527H259L583 -8H612L690 390C708 481 720 535 728 558C744 603 756 619 816 622L822 650Z"></path></g><g transform="matrix(.013,0,0,-0.013,14.542,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,25.805,0)"><path d="M249 635C141 635 70 555 70 471C70 401 114 353 179 316C143 294 106 267 90 252C68 231 45 202 45 157C45 50 130 -12 237 -12C322 -12 435 52 435 169C435 256 372 304 303 343C349 374 375 398 383 407C401 429 411 458 411 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(c) Representative transmission electron microscopic images of mitochondria in the tubular cells from scRNA- or siRNA-injected mice in the CA-AKI or CA-AKI-plus-capsaicin group.</div>

Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Capsaicin Prevents Contrast-Associated Acute Kidney Injury through Activation of Nrf2 in Mice 