Targeting Reactive Oxygen Species in Atherosclerosis via Chinese Herbal Medicines

Table 1

Detected studies reporting potential antioxidative stress effects of CHMs in atherosclerosis.

Reference	Author	Component	Experiment	Model	Relevant gene targets
[94]	J Shen	BYHWD	In vitro	HUVEC	NOX-4↓
[95]	J Guo	YXTM	In vitro	Sprague-Dawley rats	NF-κB↓, MMP-9↓, Bcl-2↓, Caspase 3↑
[96]	B Wang	TXL	In vivo	C57BL/6 mice	VEGF↑, p-VEGFR2↑, p-PI3K↑, p-AKT↑, p-eNOS↑, HO-1↑, NOX-4↓
[97]	Y Ren	SMYAD	In vivo	C57BL/6 mice	SOD-1↑, SOD-2↑
[98]	K Guo	XJEK	In vivo	Wistar rats	P-JNK↓, P-p38MAPK↓, NOX-2↓
[99]	L Wang	BSNXD	In vitro	HUVEC	ERβ↑, MDA↓, eNOS↑, NO↑, NF- κ B↓, MCP-1↓, ICAM-1↓, VCAM-1↓, E-selectin↓, CCR2 ↓, LFA-1 ↓, VLA-4 ↓
[100]	Y Yin	XMJ	In vitro	HUVEC	ICAM-1↓, VCAM-1↓, IL-1↓, IL-6↓
[101]	J Wen	TPHXR	In vivo	ApoE(-/-) mice	CAV-1↓, NF-κB p50↓, NF-κB p65↓, ICAM-1↓, VCAM-1↓, TNF-α↓, IL-6↓, IL-1β↓, hs-CRP↓, eNOS↑, NO↑
[102]	H Dong	Icariin	In vitro	Human brain vascular cerebrovascular smooth muscle cells	NOX-2↓
[103]	H Xu	Puerarin	In vitro	H9c2 cells	NOX-2↓
[104]	J Mo	Scutellarin	In vivo	Sprague-Dawley rats	NOX-4↓, SOD-1↑
[105]	Y. Li	Aucubin	In vitro	SH-SY5Y cells	TNF-α↓, IL-6↓, IL-1β↓, MDA↓, GSH↑, SOD↑, iNOS↓, NO↓
[106]	C. Shen	Bergaptol	In vitro	RAW264.7 cells	NO↓, IL-6↓, TNF-α↓, iNOS↓, IL-1β↓, COX-2↓, MAPK↓, NF-κB↓, JNK↓, p38↓, p65↓, IκBα↓, IκKα/β↓, SRA1↓, CD-36↓
[107]	U Sundar	AEPS	In vitro	HUVEC	DDAH1↑, eNOS↑
[108]	Y. Yang	KRG-WE	In vitro	RAW264.7 cells	NO↓, iNOS↓, COX↓, IFN-β↓, p38↓, JNK↓, TBK1↓, ATF-2↓, CREB↓, IRF-3↓
[109]	N. Lian	Ginkgetin	In vivo	Sprague-Dawley rats	MMP-2↓, MMP-9↓, iNOS↓, NO↑, NOS↑
[110]	Y. Liu	Honokiol	In vivo	ApoE(-/-) mice	TNF-α↓, IL-6↓, IL-1β↓, NO↓, iNOS↓
[111]	Y. Luo	TASAESs	In vivo	ApoE(-/-) mice	Caspase 3↓
[112]	Q. Zhou	OPCRR	In vivo	Wistar rats	LDL-C↓, ox-LDL↓, HDL-C↑, SOD ↑, GSH-Px↑, MDA↓, TNF-α↓, IL-1β↓, IL-6↓, ICAM-1↓, VCAM-1↓, IL-10↑, NO↓, iNOS↓, eNOS↑
[113]	Z Peng	13-MB	In vitro	HUVEC	IL-1β↓, NLRP3↓, Caspase 1↑
[114]	Q Xu	TMP	In vitro	HUVEC	PGC-1α↑, NRF1↑, TFAM↑, SIRT1↑
[115]	N Song	Gypenoside	In vitro	EA. hy926 cells	PI3K↑ AKT↑, Bad↑, Cyt-c↓, Caspase 9↓, Caspase 3↓, PARP↓
[114]	Q Xu	TMP	In vivo	Sprague-Dawley rats	PGC-1α↑, NRF1↑, TFAM↑, SIRT1↑
[115]	N Song	Gypenoside	In vivo	ApoE(-/-) mice	PI3K↑, AKT↑, Bad↑, Cyt-c↓, Caspase 9↓, Caspase 3↓, PARP↓