Review Article
Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future
Table 1
The natural products acting on SIRT1 in hemorrhagic stroke.
| Studied drugs | Mechanisms | Classes of action | Animal models | Reference |
| HLY78 | GSK3β/Sirt1/PGC-1α pathway | Antioxidation | ICH model (induced via autologous blood injection) | Jin et al. [148] | Resveratrol | NF-κB/p65 deacetylating | Anti-neuroinflammation | ICH model (intracranial injection of type IV collagenase) | Deng et al. [120] | Fucoxanthin (Fx) | Activating Sirt1 and further deacetylating FOXO and p53 | Antioxidation | SAH model (prechiasmatic cistern injection models) | Zhang et al. [150] | Salvianolic acid B (SalB) | Activating SIRT1 and Nrf2 signaling pathway | Antioxidation | SAH model (single blood injection) | Zhang et al. [153] | Melatonin (Mel) | Activating MR/Sirt1/NF-κB pathway | Anti-neuroinflammation and antioxidation | SAH model (endovascular perforation model) | Zhao et al. [158] | Berberine | Activating sirtuin 1 and suppressing HMGB1/NF-κB pathway | Anti-neuroinflammation | SAH model (prechiasmatic cistern injection models) | Zhang et al. [161] | Oleanolic acid | SIRT1-mediated HMGB1 deacetylation | Anti-neuroinflammation | SAH model (endovascular perforation model) | Han et al. [162] | Carnosic acid (CA) | Activating SIRT1/p66shc pathway | Antioxidation | SAH model (endovascular perforation model) | Teng et al. [164] | Wogonoside | Activating SIRT1 and further deregulating p53 | Anti-neuroinflammation | SAH model (endovascular perforation model) | Cheng et al. [166] |
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