Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future

Table 1

The natural products acting on SIRT1 in hemorrhagic stroke.

Studied drugs	Mechanisms	Classes of action	Animal models	Reference
HLY78	GSK3β/Sirt1/PGC-1α pathway	Antioxidation	ICH model (induced via autologous blood injection)	Jin et al. [148]
Resveratrol	NF-κB/p65 deacetylating	Anti-neuroinflammation	ICH model (intracranial injection of type IV collagenase)	Deng et al. [120]
Fucoxanthin (Fx)	Activating Sirt1 and further deacetylating FOXO and p53	Antioxidation	SAH model (prechiasmatic cistern injection models)	Zhang et al. [150]
Salvianolic acid B (SalB)	Activating SIRT1 and Nrf2 signaling pathway	Antioxidation	SAH model (single blood injection)	Zhang et al. [153]
Melatonin (Mel)	Activating MR/Sirt1/NF-κB pathway	Anti-neuroinflammation and antioxidation	SAH model (endovascular perforation model)	Zhao et al. [158]
Berberine	Activating sirtuin 1 and suppressing HMGB1/NF-κB pathway	Anti-neuroinflammation	SAH model (prechiasmatic cistern injection models)	Zhang et al. [161]
Oleanolic acid	SIRT1-mediated HMGB1 deacetylation	Anti-neuroinflammation	SAH model (endovascular perforation model)	Han et al. [162]
Carnosic acid (CA)	Activating SIRT1/p66shc pathway	Antioxidation	SAH model (endovascular perforation model)	Teng et al. [164]
Wogonoside	Activating SIRT1 and further deregulating p53	Anti-neuroinflammation	SAH model (endovascular perforation model)	Cheng et al. [166]