Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future

Table 2

The natural products acting on SIRT1 in hemorrhagic stroke.

Studied drugs	Mechanisms	Classes of action	Animal models	Reference
Adiponectin (APN)	Activating SIRT1/PGC-1α	Antioxidation	Glutamate- (Glu-) induced excitotoxicity in mouse HT22 hippocampal cells	Yue et al. [53]
Salvianolic acid B (SalB)	Downregulation of Ac-FOXO1	Anti-neuroinflammation and antioxidation	Middle cerebral artery occlusion (MCAO) model	Lv et al. [109]
Alpha-lipoic acid	Activating SIRT1/PGC-1α pathway	Antioxidation	MCAO	Fu et al. [186]
Astragaloside IV (AS-IV)	Activating Sirt1/Mapt pathway	Antioxidation	MCAO	Shi et al. [85]
Arctigenin (ARC)	NLRP3 inflammasome	Anti-neuroinflammation	MCAO	Zhang et al. [142]
Quercetin	Activating SIRT1/Nrf2 pathway	Antioxidation	MCAO	Yang et al. [177]
Momordica charantia polysaccharides (MCPs)	Activating SIRT1/β-catenin pathway	Antioxidation	MCAO	Hu et al. [179]
Icariin (ICA)	Activating SIRT1/PGC-1α pathway	Antioxidation	MCAO	Zhu et al. [180]
Kaempferol (KFL)	Activating SIRT1/P66shc pathway	Antioxidation	Oxygen and glucose deprivation (OGD)	Zhou and Li [182]
Calycosin-7-O-β-D-glucoside (CG)	Activating SIRT1/FOXO1/PGC-1α pathway	Antioxidation	OGD	Yan et al. [58]
Notoginseng leaf triterpenes (PNGL)	Activating SIRT1/2/3-Foxo3a-MnSOD/PGC-1α pathways	Antioxidation	OGD	Xie et al. [183]
Cycloastragenol (CAG)	Suppression of SIRT1/NF-κB activation	Anti-neuroinflammation	MCAO	Li et al. [185]
Piceatannol	Activating Sirt1/FoxO1 pathway	Antioxidation	MCAO	Wang et al. [168]