Wheel-Running Exercise Protects Ovariectomized Mice from Bone Loss via IFN-γ-Mediated Suppression of the NF-κB and MAPK Pathways

Figure 2

WR exercise decreased body weights and alleviated bone loss in OVX mice. (a) A schematic diagram of the treatments. (b) The body weights of different groups ( mice for each group). (c) Representative μ-CT images. (d) μ-CT analyses of BMD, BV/TV, Tb. N, Tb. Th, and Tb. Sp ( samples for each group). (e) Representative images of H&E staining. S: sham-operated mice; S + WR: sham-operated mice treated with WR exercise; OVX: ovariectomy mice; OVX + WR: OVX mice treated with WR exercise (P <0.05).

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