Research Article
Wheel-Running Exercise Protects Ovariectomized Mice from Bone Loss via IFN-γ-Mediated Suppression of the NF-κB and MAPK Pathways
Table 2
Main results of in vivo experiments.
| | Groups | value | | Parameters | | | OVX | | OVX vs. S | vs. | vs. OVX |
| | Body weight (g) | | | | | < 0.05 | < 0.05 | < 0.05 | | Trabecular bone | | | | | | | | | BMD (g/cm3) | | | | | < 0.05 | > 0.05 | < 0.05 | | BV/TV (%) | | | | | < 0.05 | > 0.05 | < 0.05 | | Tb. N (1/mm) | | | | | < 0.05 | > 0.05 | < 0.05 | | Tb. Th (um) | | | | | < 0.05 | > 0.05 | < 0.05 | | Tb. Sp (mm) | | | | | < 0.05 | > 0.05 | < 0.05 | | Serum P1NP level (pg/mL) | | | | | < 0.05 | > 0.05 | > 0.05 | | Serum CTX-1 level (ng/mL) | | | | | < 0.05 | > 0.05 | < 0.05 | | CD4+ T in spleen (%) | | | | | > 0.05 | > 0.05 | > 0.05 | | CD4+ T in BM (%) | | | | | > 0.05 | > 0.05 | > 0.05 | | CD8+ T in spleen (%) | | | | | < 0.05 | > 0.05 | < 0.05 | | CD8+ T in BM (%) | | | | | < 0.05 | > 0.05 | < 0.05 | | IFN-γ+ in spleen (%) | | | | | < 0.05 | > 0.05 | < 0.05 | | CD8+ IFN-γ+ in spleen (%) | | | | | < 0.05 | > 0.05 | < 0.05 | | Serum IFN-γ level (pg/mL) | | | | | < 0.05 | > 0.05 | < 0.05 |
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