Silk Fibroin Hydrogels Could Be Therapeutic Biomaterials for Neurological Diseases

Table 1

List of the applications of SF or SF blends.

Application	Materials	In vitro	In vivo	Cite
Cartilage tissue engineering	GMA/SF	Human chondrocytes	Female athymic mice, rabbits	[59]
Bone defect repair	n-HA-GO/SF	Rabbit bone marrow mesenchymal stem cells (BMSCs)	Male mice critical-sized bone defect models	[60]
Ligament reconstruction	SF/HA-SF	Rat BMSCs	Rabbit models of ACLR	[61]
Wound healing	CF@GO/SF	Human fibroblast (L929) cells	Rat models of wound	[62]
Reconstitution of cardiac function	SF	Rat quiescent ventricular cardiomyocytes	Left ventricles of rats	[63]
Vascular remolding	SF/GT	Mouse BMSCs	/	[64]
Trachea reconstruction	SF/CVM	Human-induced pluripotent stem cells (hiPSCs)	Porcine tracheal defect models	[65]
Artificial cornea engineering	PVA/SF/n-HA/GP	Human corneal fibroblasts (HCFs)	/	[66]
Enamel regeneration	SF/HA	/	/	[67]
Hepatic tissue engineering	SF	Stem cells from human exfoliated deciduous teeth (SHED)	/	[68]
Bladder reconstruction	SF	Adipose-derived stem cells (ASCs)	Rat bladder augmentation models	[69]
Nucleus pulposus replacement	SF/PU	/	Rabbits	[70]
Nerve regeneration	Collagen/SF	Human umbilical cord mesenchymal stem cells (hUC-MSCs)	Rat models of SCI	[71]
Tumor therapy	Biliverdin/SF	/	Mice tumor models	[49]
Drug delivery	DEX/CSNPs/SF	L929 fibroblast cell line	/	[72]

GMA: glycidyl methacrylate; n-HA: nanohydroxyapatite; GO: graphene oxide; ACLR: anterior cruciate ligament reconstruction; CF: ciprofloxacin; GT: gelatin-tyramine; CVM: collagen vitrigel membrane; GP: genipin; PU: polyurethane; SCI: spinal cord injury; DEX: dexamethasone; CSNPs: chitosan nanoparticles.