Silk Fibroin Hydrogels Could Be Therapeutic Biomaterials for Neurological Diseases

Table 2

List of the published clinical trials that highlight the application of silk-based materials.

No.	Intervention/treatment	Condition/disease	Number of participants	Compete date	Clinical trial identifier
1	Device: The SF patch or paper patch	Diseases of the ear and mastoid process	60	June 2012	KCT0000305
2	Device: HQ® matrix medical wound dressing; Device: Sidaiyi® wound dressing	Donor site wound	71	September 2014	NCT01993030
3	Device: silk fibroin with bioactive coating layer dressing	Late complication from skin graft; infection of skin donor site; impaired wound healing; pain, intractable	29	May 2015	NCT02091076
4	Bilayer scaffold composed of amniotic membrane and silk fibroin	Diabetes mellitus; Wagner ulcer grade II	20	February 2018	IRCT2016071328903N1
5	Absorbable SF membrane	Alveolar ridge preservation after tooth extraction	65	December 2018	ChiCTR1800016759
6	Autologous chondrocytes seeded in SF scaffolds	Osteochondral defects	15	July 2019	IRCT2017062434731N1
7	SF membrane combined with xenograft	K053-chronic periodontitis	15	December 2019	CTRI/2018/12/016509
8	Serioss® (SF scaffold)	Patients undergoing surgery for bone void filling	10	/	CTRI/2021/01/030589
9	Device: Silk Bridge	Peripheral nerve injury digital nerve hand	4	March 2021	NCT03673449
10	Silk sericin dressing with collagen	Wound heal; wound surgical; donor site complication	30	December 2021	NCT04743375
11	Procedure: Silk microparticle filler injection	Vocal cord paralysis unilateral; dysphonia; dysphagia, oropharyngeal	100	September 2024	NCT03790956

Source: data retrieved from International Clinical Trials Registry Platform.