Exacerbation of Thrombotic Responses to Silver Nanoparticles in Hypertensive Mouse Model

<div>In vitro platelet aggregation in whole blood collected from normotensive (NT) or hypertensive (HT) mice after intratracheal (i.t.) instillation of saline or polyethylene glycol silver nanoparticles (PEG-AgNPs). Blood samples obtained from the aforementioned groups were incubated at 37°C with ADP (0.1 <i>μ</i>M) for 3 min and stirred for another 3 min, and single platelets were then counted. The degree of platelet aggregation in HT or NT mice exposed to PEG-AgNPs or saline was compared with each other and with that obtained in untreated (without ADP) whole blood obtained from control (unexposed) mice. 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Oxidative Medicine and Cellular Longevity

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Figure 4

Figure 4: Exacerbation of Thrombotic Responses to Silver Nanoparticles in Hypertensive Mouse Model 