Gliclazide in Binary and Ternary Systems Improves Physicochemical Properties, Bioactivity, and Antioxidant Activity

Table 4

Kinetic models of drug release.

Formulation code	Zero-order model		First-order model		Higuchi model		Korsmeyer-Peppas model			Hixson-Crowell model
	Control (gli)	0.89	3.93	0.99	0.54	0.99	12.20	0.93	4.87	0.52	0.88	0.01
PM 1 : 1	0.98	2.24	0.94	0.65	0.98	15.35	0.94	5.58	0.60	0.95	0.01
PM 1 : 2.5	0.78	4.87	0.85	0.18	0.94	14.66	0.94	4.84	0.44	0.84	0.05
PM 1 : 4	0.88	5.58	0.86	0.62	0.95	14.09	0.95	2.89	0.38	0.92	0.07
PM 1 : 9	0.92	4.84	0.85	0.679	0.97	23.32	0.94	3.27	0.36	0.91	4.87
PM 1 : 1 : 0.27	0.96	2.89	0.86	0.05	0.98	2.20	0.96	14.03	0.45	0.80	5.58
PM 1 : 1  : 1	0.98	3.27	0.84	0.03	0.96	3.78	0.95	15.66	0.45	0.83	4.84
PM 1 : 2.5 : 0.27	0.83	5.48	0.96	0.46	0.95	4.61	0.93	15.71	0.48	0.87	2.89
PM 1 : 3.6 : 3.6	0.89	6.93	0.96	0.54	0.96	3.20	0.96	11.49	0.54	0.88	0.54
PM 1 : 4 : 1	0.98	7.24	0.93	0.55	0.98	3.35	0.94	10.11	0.55	0.95	0.55
PM 1 : 9 : 1	0.78	8.87	0.86	0.48	0.93	13.66	0.93	28.64	0.48	0.84	0.48
SE 1 : 1	0.88	4.58	0.87	0.62	0.93	18.09	0.95	38.95	0.62	0.92	0.62
SE 1 : 2.5	0.92	8.84	0.83	0.49	0.92	19.32	0.94	42.29	0.36	0.91	0.54
SE 1 : 4	0.86	6.89	0.84	0.44	0.99	12.20	0.95	14.03	0.45	0.80	0.01
SE 1 : 9	0.98	4.27	0.88	0.56	0.99	13.78	0.94	15.66	0.45	0.83	0.02
SE 1 : 1 : 0.27	0.93	4.48	0.95	0.66	0.94	14.61	0.94	15.71	0.48	0.87	0.02
SE 1 : 1 : 1	0.99	5.93	0.97	0.54	0.97	2.20	0.93	11.49	0.52	0.88	0.01
SE 1 : 2.5 : 0.27	0.98	5.24	0.94	0.55	0.97	13.35	0.95	10.11	0.60	0.95	0.01
SE 1 : 3.6 : 3.6	0.98	6.87	0.87	0.58	0.98	24.66	0.95	28.64	0.44	0.84	0.05
SE 1 : 4 : 1	0.98	5.58	0.86	0.32	0.95	28.09	0.93	38.95	0.38	0.92	0.07
SE 1 : 9:1	0.92	7.84	0.84	0.59	0.94	29.32	0.94	42.29	0.36	0.91	0.07