Curcumin Inhibits Hyperandrogen-Induced IRE1<i>α</i>-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats

<div>The curcumin effects on body weight, ovarian weight, and abdominal fat in DHEA-induced PCOS-like rats. PCOS-like rats were induced with DHEA-exposed, together with or without curcumin treatment. (a, b) Rat body weight and ovarian weight were measured in all experimental groups after 8 weeks of curcumin treatment. (c) A macroscopic view of the abdominal fat of each group of rats was shown. (d, e) Abdominal fat in all experimental group rats was assessed by H&amp;E staining (20x) and the quantitative analysis. Three independent experiments were performed with similar results. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Curcumin Inhibits Hyperandrogen-Induced IRE1<i>α</i>-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats 

Figure 1 | Curcumin Inhibits Hyperandrogen-Induced IRE1α-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats 