Curcumin Inhibits Hyperandrogen-Induced IRE1<i>α</i>-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats

<div>Curcumin relieves the ER stress strongly activated by DHEA in the ovarian tissue of PCOS-like rats. (a) The levels of p-IRE1<i>α</i> and XBP1 were measured with immunohistochemical staining. (b) The expression of IRE1<i>α</i>, XBP1, GRP-78, and CHOP in the ovaries was assessed by qRT-PCR assay. (c, d) The protein expression of p-IRE1<i>α</i>, IRE1<i>α</i>, XBP1, GRP-78, and CHOP in ovarian tissues was assessed with western blotting. Representative data are displayed, and the relative protein intensity of p-IRE1<i>α</i>, IRE1<i>α</i>, XBP1, GRP-78, and CHOP was normalized to GAPDH. Three independent experiments were performed with similar results. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Curcumin Inhibits Hyperandrogen-Induced IRE1<i>α</i>-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats 

Figure 2 | Curcumin Inhibits Hyperandrogen-Induced IRE1α-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats 