Curcumin Inhibits Hyperandrogen-Induced IRE1<i>α</i>-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats

<div>Curcumin activates the PI3K/AKT pathway inhibited by DHT in ovary GCs. Curcumin/LY294002-treated GCs were induced by DHT. (a–d) Round coverslips of ovarian GCs were immunostained for revealing p-PI3K and p-AKT expression levels (red) as indicated. The slides were counterstained with DAPI (blue), and the images were captured using an inverted fluorescence microscope. (e, f) The protein expression of p-PI3K, PI3K, AKT, and p-AKT in ovarian GCs was assessed with western blotting. Representative data are displayed, and the relative protein intensity of p-PI3K, PI3K, AKT, and p-AKT was normalized to GAPDH. Three independent experiments were performed with similar results. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Curcumin Inhibits Hyperandrogen-Induced IRE1<i>α</i>-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats 

Figure 5 | Curcumin Inhibits Hyperandrogen-Induced IRE1α-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats 