Curcumin Inhibits Hyperandrogen-Induced IRE1<i>α</i>-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats

<div>Ameliorative effects of curcumin on DHT-induced ER stress in ovarian GCs mediated via increasing of PI3K/AKT phosphorylation. (a, b) Western blot results showing the changes in the indicated proteins in GCs treated with DHT after incubation with LY294002 (a PI3K inhibitor). (c, d) The p-IRE1<i>α</i> protein level in GCs treated with DHT, LY294002, and curcumin. (e, f) Changes in ER stress-related protein levels in GCs treated with DHT and LY294002 as detected by western blot. Three independent experiments were performed with similar results. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Curcumin Inhibits Hyperandrogen-Induced IRE1<i>α</i>-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats 

Figure 6 | Curcumin Inhibits Hyperandrogen-Induced IRE1α-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats 