Four-Octyl Itaconate Protects Chondrocytes against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling

<div>OI inhibited H<sub>2</sub>O<sub>2</sub>-stimulated cell death and apoptosis in primary murine chondrocytes. Primary murine chondrocytes were added with OI (25 <i>μ</i>M) or vehicle control (“Veh”), followed by H<sub>2</sub>O<sub>2</sub> (300 <i>μ</i>M) stimulation. Cell viability (a), cell death (b), caspase-3 activity (c), accumulation of single-stranded DNA (ssDNA) contents (d), and apoptosis (e) were assessed. (f, g) Annexin V FACS assays were performed. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Four-Octyl Itaconate Protects Chondrocytes against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling 

Figure 2 | Four-Octyl Itaconate Protects Chondrocytes against H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling 