Four-Octyl Itaconate Protects Chondrocytes against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling

<div>Schematic of the chondroprotective effect of OI via the Nrf2 pathway. OI protects chondrocytes against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress by activating Nrf2, which translocates into the nucleus to increase the transcription and expression of Nrf2-dependent antioxidant proteins (HO1, NQO1, and GCLC), and then attenuates OA progression.</div>

Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Four-Octyl Itaconate Protects Chondrocytes against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling 

Figure 7 | Four-Octyl Itaconate Protects Chondrocytes against H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling 