Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish

Figure 9

Effect of TMP on insufficient angiogenesis in Flik zebrafish embryos. (a) The 1 dpf Flik zebrafish larvae were treated with 0.1% DMSO, 0.2 μg/mL PTK787, various concentrations of TMP (10, 20, and 40 μg/mL) cotreated with PTK787 for 24 h. Red and white arrow indicate the defective ISV and intact ISV of zebrafish, respectively. (b) Quantitative analysis showing TMP inhibited PTK787-induced ISVs deficiency. Values are presented as . , , vs. control group; , , vs. PTK787 group.

(a)

(b)