NRF3 Decreases during Melanoma Carcinogenesis and Is an Independent Prognostic Marker in Melanoma

Figure 1

mRNA expression. (a) Pooled Gene Expression Omnibus data from three different cDNA microarray studies including the expression levels of NRF3 show varying levels between benign, dysplastic, and malignant conditions. The only observed statistical significance is indicated. (b) A TIMER2.0 expression plot based on TCGA database sample sets [18]. Skin cutaneous melanoma and melanoma metastasis groups are highlighted with a red box. NFE2L3 mRNA levels increase significantly between melanoma tumour and metastasis groups ( value < 0.001).

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