Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage

Figure 3

Pinocembrin activated SIRT1-mediated signaling following SAH. (a) Protein bands of SIRT1, Pgc-1a, and ac-NF-κB after pinocembrin treatment. Pinocembrin upregulated SIRT1 (b) and Pgc-1a (c) levels and suppressed ac-NF-κB (d) expression after SAH. (e) Representative photomicrographs of SIRT1 staining in brain tissue at 24 h post-SAH. (f) Pinocembrin resulted in enhanced SIRT1 staining at 24 h post-SAH. Scale  μm. Values were presented as , per group. .

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