Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage

<div>Pinocembrin alleviated free radical injury after SAH. Measurement of intracellular MDA (a), SOD (b), GSH (c), and CAT (d) after pinocembrin treatment. (e) Protein bands of 3-nitrotyrosine after pinocembrin treatment. (f) Pinocembrin suppressed 3-nitrotyrosine expression after SAH. (g) Representative images of 8-OhdG staining in brain tissue. (h) Pinocembrin resulted in decreased 8-OhdG staining at 24 h post-SAH. In contrast, Ex-527 abrogated the antifree radical effects of pinocembrin. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage 