Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage

Figure 5

Pinocembrin mitigated post-SAH inflammatory injury. ELISA was used to detect proinflammatory cytokine release. Pinocembrin decreased the levels of IL-1β (a), IL-6 (b), and ICAM-1 (c) after SAH damage. (d) Representative photomicrographs of Iba1 staining in brain tissue at 24 h post-SAH. (e) Pinocembrin resulted in decreased microglia activation at 24 h post-SAH. In contrast, Ex-527 abrogated the anti-inflammatory effects of pinocembrin. Scale  μm. Values were presented as , per group. .

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