Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage

<div>Pinocembrin reduced neuronal apoptosis and improved neurological outcomes after SAH. (a) Representative photomicrographs of TUNEL staining in brain tissue at 24 h post-SAH. (b) Pinocembrin decreased neuronal apoptosis at 24 h post-SAH. Pinocembrin improved mNSS score (c) and motor behavior (d) after SAH. Ex-527 abated the cerebroprotective effects of pinocembrin after SAH. (e) Representative photomicrographs of cresyl violet-stained images. (f) Pinocembrin improved neuronal survival at 72 h post-SAH, which could be reversed by Ex-527 pretreatment. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage 