Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis-Induced Acute Lung Injury through GSK3β/Keap1-Nrf2-GPX4 Pathway

Figure 4

Inhibiting MUC1 triggered ferroptosis in lung tissues and alveolar epithelial cells of sepsis. (a, b) Western blot assay was conducted to evaluate the effect of MUC1 inhibitor GO203 on GPX4 expression in lung tissues of septic mice. (c–f) The expression levels of redox products in lung tissues of septic mice; (g, h) Flow cytometry was used to detect the levels of lipid peroxides in MLE-12 cells. (i) TEM evaluation of the effects of GO203 on the morphology of ferroptosis-related organelles in MLE-12 cells. All data were expressed in the form of ; , , and .

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