Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis-Induced Acute Lung Injury through GSK3β/Keap1-Nrf2-GPX4 Pathway

Figure 7

MUC1 sensitized vitamin E to inhibit ferroptosis and relieve lung injury. (a) HE staining results in each group. (b) Lung injury score in each group. (c) Wet-dry weight ratio of lung tissues in each group. (d–g) Levels of TNF-α, IL-1β, IL-6, and IL-10 in sera of each group. (h–k) Levels of TNF-α, IL-1β, IL-6, and IL-10 in BALF of each group. (l, m) Flow cytometry was used to detect the levels of lipid peroxides in MLE-12 cells in each group. All data were expressed in the form of ; , , and .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)

(m)