Review Article
Carica papaya L. Leaves: Deciphering Its Antioxidant Bioactives, Biological Activities, Innovative Products, and Safety Aspects
Table 4
Immunomodulatory potential of papaya leaf extract.
| Treatment | Results | References |
| Oral administration of SCPLE (150 mg/kg) in thrombocytopenic rats | Significant () increase in thrombocytes ( cells/mm3), DTH response (), and phagocytic index | [63] | Administration of C. papaya and methanol (MeOH) extracts on mice for 3 weeks. | Proinflammatory cytokines (IL-10, IL-12, IL-1β, IL-6, and TGF-β1) were decreased. | [80] | Aqueous-extracted CP leaf fraction on the growth of various tumor cell lines | Production of IL-2 and IL-4 was reduced. IL12p40, IL-12p70, IFN-, and TNF- were enhanced without growth inhibition | [36] |
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