STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway

<div>Autophagy-related genes and Nrf2 signaling pathway were decreased with blockade of VDR. BEAS-2B cells were transfected with either Ctrl siRNA or VDR siRNA for 24 h in serum-free medium and then received indicated medium from THP-1 cells (Ctrl and particle groups) with or without IL4 treatment for another 24 h. The total RNA was extracted, and qRT-PCR assay was employed to measure the mRNA expression of (a) VDR, (b) CYP24A, (c) Beclin1, (d) LC3B, (e) Nrf2, and (f) GCS. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway 