STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway

Figure 8

Proposed model for the STAT6/VDR axis mitigates lung inflammatory. STAT6 activation enhances the translocation of VDR to the nucleus, which increased the transcription of autophagy-related genes and then induced Nrf2 signaling, preventing oxidative stress, DNA damage, and apoptosis.