Oxidative Medicine and Cellular Longevity / 2022 / Article / Tab 2 / Review Article
Epigenetic Changes and Functions in Pneumoconiosis Table 2 The main lncRNA changes involved in pneumoconiosis.
lncRNA Regulation Model Target gene and signal pathway Reference Patients In vivo In vitro Rat Mouse Macrophage Fibroblast Alveolar epithelial cell lncRNA-ATB Up √ A549, Beas-2B lncRNA-ATB adsorbed miR-200c and released ZEB1, promoting the occurrence of EMT. [99 –101 ] lncRNA-MALAT1 Up A549, HBE lncRNA-MALAT1 can promote EMT by regulating the PI3K/AKT/SNAIL-signaling pathway by targeting miR-503 and targeting PI3K and p85. [94 ]、 [95 ] lncRNA-CHRF Up RAW264.7, THP-1 macrophages NIH/3T3, MRC-5 lncRNA-CHRF can adsorb miR-489. (1) miR-489 inhibited the expression of MyD88, IL-1β and TGF-β 1 in mice and macrophages (2) miR-489 inhibited total SMAD3 and p-SMAD3 levels and alleviated pulmonary fibrosis in mice and fibroblasts [92 ]、 [93 ] lncRNA-HOTAIR Up A549, HBE lncRNA-HOTAIR regulates the pulmonary inflammatory process by targeting miR-326 to regulate TNFSF14. [91 ] LOC103691771 Up √ Rat primary lung fibroblasts LOC103691771 promotes differentiation of myofibroblasts by regulating the TGF-β –SMAD2/3 signaling pathway. [134 ] LOC102549714 Up √ [134 ] LOC102550137 Up √ [134 ] NONRATT015512.2 Up √ [135 ] NONRATT017365.2 Up √ [135 ] ENSRNOT00000054583.1 Up √ [135 ] ENSRNOT00000048692 Up √ [135 ] ENSRNOT00000054495.1 Up √ [135 ] NONRATT016740.2 Up √ [135 ] NONRATT006104.2 Up √ [135 ] NONRATT002987.2 Up √ [135 ] NONRATT009275.2 Up √ [135 ] ENSRNOT00000001712 Up √ [135 ] LOC103693125 Down √ [134 ] LOC103692016 Down √ [134 ] NONRATT030230.2 Down √ [135 ] NONRATT024771.2 Down √ [135 ] NONRATT009769.2 Down √ [135 ] NONRATT022710.2 Down √ [135 ] NONRATT001412.2 Down √ [135 ] NONRATT011944.2 Down √ [135 ] NONRATT011539.2 Down √ [135 ] ENSRNOT00000014917 Down √ [135 ] ENSRNOT00000083823.1 Down √ [135 ] NONRATT029573.2 Down √ [135 ]