Sitagliptin Alleviates Radiation-Induced Intestinal Injury by Activating NRF2-Antioxidant Axis, Mitigating NLRP3 Inf--lammasome Activation, and Reversing Gut Microbiota Disorder

Figure 1

Sitagliptin alleviates intestinal damage in mice with WAI. (a) Operational diagram of the animal experiment with WAI. (b, c) Body weight and survival analysis of mice in the Con (), Sitagliptin (), WAI (), and WAI+Sitagliptin () groups. (d) Macroscopic appearance of the intestine in each group. (e, f) Colon length in each group. (g) H&E staining of the small intestine from indicated groups. Scale bars, 100 μm. (h) PAS staining analysis of the small intestine from indicated groups. (i) Quantification of goblet cells based on PAS staining. Scale bars, 100 μm, .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)