Sitagliptin Alleviates Radiation-Induced Intestinal Injury by Activating NRF2-Antioxidant Axis, Mitigating NLRP3 Inf--lammasome Activation, and Reversing Gut Microbiota Disorder

Figure 2

Sitagliptin inhibits intestinal inflammation and promotes the regeneration of intestinal epithelial cells in irradiated mice. (a) mRNA level of TNFα in small intestinal tissues, . (b) mRNA level of IL-6 in small intestinal tissues, . (c) mRNA level of IL-1β in small intestinal tissues. (d–g) IHC staining of Lgr5⁺, Ki67⁺, Lysozyme⁺, and Villin⁺ cells in small intestinal tissues. Scale bars, 100 μm.

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