Fetal Zone Steroids Show Discrete Effects on Hyperoxia-Induced Attenuation of Migration in Cultured Oligodendrocyte Progenitor Cells

Figure 1

Hyperoxia leads to impairment of migration-related pathways in OLN93 cells. Enrichment of altered proteins () in OLN93 cells post-24-hour 80% O₂ in comparison to normoxic control treatment in specific functional categories was analysed using IPA: (a) canonical pathways; (b) disease or functions. Heat-map representation of enriched categories are sorted by -score. Negative -scores representing inhibition are indicated in blue, and positive values representing activation are indicated in red. Categories with a -score above 2 or below -2 are only shown. Color code bar represents the maximum and minimum values in accordance to the color. Relevant categories are marked in italics. Cutoff value < 0.05 (Fisher’s exact test). All results were obtained from the analysis of data of five independent experiments.

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