Fetal Zone Steroids Show Discrete Effects on Hyperoxia-Induced Attenuation of Migration in Cultured Oligodendrocyte Progenitor Cells

Figure 4

Adiol alters regulation of pathways affected by hyperoxia. (a) Canonical pathway analysis of significantly enriched proteins in the OLN93 cells post different treatment conditions with adiol in comparison to normoxic and hyperoxic controls using IPA. Heat-map representation of enriched pathways sorted by -score. Higher negative -score is indicated in blue, and higher positive -score values are indicated in red. Cutoff value < 0.05 (Fisher’s exact test). (b) Heat-map representation of cell migration-related proteins that were dysregulated in the different treatment groups with adiol post-24-hour 80% O₂ treatment in comparison to normoxic and hyperoxic controls. Protein abundance ratios are depicted with a color scale (downregulated proteins are indicated in blue, intermediate in grey, and upregulated proteins in red). Proteins are sorted according to Gene Ontology (biological process). Dark outlined cells represent the significantly altered proteins () in each group. All data are representative of five independent experiments.

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