Review Article
Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development
Figure 5
ROS sources in malignant cells and their role in promoting cell proliferation. There are many sources of ROS in malignant cells, including cytokines, growth factors, NOXs, Mito-ETC, and oncogenes. Higher ROS levels facilitate the aberrant proliferation of cancer cells by regulating various signaling pathways.